Clinical aspects and biological bases of drug-resistant epilepsies

@article{Regesta1999ClinicalAA,
  title={Clinical aspects and biological bases of drug-resistant epilepsies},
  author={Giovanni Regesta and Paolo Tanganelli},
  journal={Epilepsy Research},
  year={1999},
  volume={34},
  pages={109-122}
}
The definition of drug-resistant epilepsy (DRE) is elusive and still controversial owing to some unresolved questions such as: how many drugs should be tried before a patient is considered intractable; to which extent side-effects may be acceptable; how many years are necessary before establishing drug resistance. In some cases, the view of epilepsy as a progressive disorder constitutes another important issue. Despite the use of new antiepileptic drugs (AEDs), intractable epilepsy represents… CONTINUE READING
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