Clinical applications of fluorescence in situ hybridization.

  title={Clinical applications of fluorescence in situ hybridization.},
  author={Douglas C. Tkachuk and Daniel Pinkel and Wen Lin Kuo and H U Weier and Joe W. Gray},
  journal={Genetic analysis, techniques and applications},
  volume={8 2},
We review here the application of fluorescence in situ hybridization with chromosome-specific probes to chromosome classification and to detection of changes in chromosome number or structure associated with genetic disease. Information is presented on probe types that are available for disease detection. We discuss the application of these probes to detection of numerical aberrations important for prenatal diagnosis and to detection and characterization of numerical and structural aberrations… CONTINUE READING