Clinical application of tissue engineered human heart valves using autologous progenitor cells.

@article{Cebotari2006ClinicalAO,
  title={Clinical application of tissue engineered human heart valves using autologous progenitor cells.},
  author={Serghei Cebotari and Artur Lichtenberg and I. S. Tudorache and Andres Hilfiker and H. Mertsching and Rainer G. Leyh and Thomas Breymann and Klaus Kallenbach and Liviu Maniuc and Aurel Batrinac and O. S. Repin and Oxana Maliga and Anatol Ciubotaru and Axel Haverich},
  journal={Circulation},
  year={2006},
  volume={114 1 Suppl},
  pages={
          I132-7
        }
}
BACKGROUND Tissue engineering (TE) of heart valves reseeded with autologous cells has been successfully performed in vitro. Here, we report our first clinical implantation of pulmonary heart valves (PV) engineered with autologous endothelial progenitor cells (EPCs) and the results of 3.5 years of follow-up. METHODS AND RESULTS Human PV allografts were decellularized (Trypsin/EDTA) and resulting scaffolds reseeded with peripheral mononuclear cells isolated from human blood. Positive stain for… CONTINUE READING

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