Clinical application of time-dependent sensitization to antidepressant therapy

  title={Clinical application of time-dependent sensitization to antidepressant therapy},
  author={Seymour M. Antelman and Samuel Gershon},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
1. A number of animal studies have shown that the actions of numerous drugs can grow or sensitize with the passage of time following even a single treatment, to achieve results equal to or greater than those seen after chronic administration. 2. Our laboratory earlier proposed that this principle might be applied to the treatment of human disorders. It was suggested that the same results might be achieved by giving drugs once every one or two weeks rather than daily, or, even more likely… CONTINUE READING

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Progress in Neuro-Psychopharmacology and Biological Psychiatry • 2011
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