Clinical application of scaffolds for cartilage tissue engineering

  title={Clinical application of scaffolds for cartilage tissue engineering},
  author={Junji Iwasa and Lars Engebretsen and Yosuke Shima and Mitsuo Ochi},
  journal={Knee Surgery, Sports Traumatology, Arthroscopy},
  pages={561 - 577}
The purpose of this paper is to review the basic science and clinical literature on scaffolds clinically available for the treatment of articular cartilage injuries. The use of tissue-engineered grafts based on scaffolds seems to be as effective as conventional ACI clinically. However, there is limited evidence that scaffold techniques result in homogeneous distribution of cells. Similarly, few studies exist on the maintenance of the chondrocyte phenotype in scaffolds. Both of which would be… CONTINUE READING