Clinical application of microencapsulated islets: actual prospectives on progress and challenges.

@article{Calafiore2014ClinicalAO,
  title={Clinical application of microencapsulated islets: actual prospectives on progress and challenges.},
  author={Riccardo Calafiore and Giuseppe Basta},
  journal={Advanced drug delivery reviews},
  year={2014},
  volume={67-68},
  pages={84-92}
}
After 25 years of intense pre-clinical work on microencapsulated intraperitoneal islet grafts into non-immunosuppressed diabetic recipients, the application of this procedure to patients with type 1 diabetes mellitus has been a significant step forward. This result, achieved in a few centers worldwide, underlies the safety of biopolymers used for microencapsulation. Without this advance, no permission for human application of microcapsules would have ever been obtained after years of… CONTINUE READING
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