Clinical application of a rapid lung-orientated immunoassay in individuals with possible tuberculosis.

@article{Breen2008ClinicalAO,
  title={Clinical application of a rapid lung-orientated immunoassay in individuals with possible tuberculosis.},
  author={Ronan Angus MacCormick Breen and Simon M Barry and Colette Joanne Smith and Robert John Shorten and John Paul Dilworth and Ian M Cropley and Timothy D McHugh and Stephen H. Gillespie and George Janossy and Marc Caeroos Isaac Lipman},
  journal={Thorax},
  year={2008},
  volume={63 1},
  pages={67-71}
}
BACKGROUND Immunological ex vivo assays to diagnose tuberculosis (TB) have great potential but have largely been blood-based and poorly evaluated in active TB. Lung sampling enables combined microbiological and immunological testing and uses higher frequency antigen-specific responses than in blood. METHODS A prospective evaluation was undertaken of a flow cytometric assay measuring the percentage of interferon-gamma synthetic CD4+ lymphocytes following stimulation with purified protein… CONTINUE READING