Clinical and toxicological relevance of CYP2C9: drug-drug interactions and pharmacogenetics.

@article{Rettie2005ClinicalAT,
  title={Clinical and toxicological relevance of CYP2C9: drug-drug interactions and pharmacogenetics.},
  author={Allan E Rettie and Jeffrey P. Jones},
  journal={Annual review of pharmacology and toxicology},
  year={2005},
  volume={45},
  pages={
          477-94
        }
}
CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic clearance of a wide variety of therapeutic agents, including nonsteroidal antiinflammatories, oral anticoagulants, and oral hypoglycemics. Disruption of CYP2C9 activity by metabolic inhibition or pharmacogenetic variability underlies many of the adverse drug reactions that are associated with the enzyme. CYP2C9 is also the first human P450 to be crystallized, and the structural basis for its substrate and inhibitor… CONTINUE READING

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