Clinical and toxicological consequences of the inductive potential of ethanol

  title={Clinical and toxicological consequences of the inductive potential of ethanol},
  author={U. Klotz and E. Ammon},
  journal={European Journal of Clinical Pharmacology},
  • U. Klotz, E. Ammon
  • Published 1998
  • Medicine, Chemistry
  • European Journal of Clinical Pharmacology
  • Abstract Variability in drug metabolism is an important factor that accounts for individual responsiveness to xenobiotics. Enzyme induction which leads to a more rapid elimination of foreign compounds and to a more extensive formation of potentially active metabolites significantly contributes to large interindividual variability in drug effects.Ethanol is consumed worldwide in tremendous amounts and is an effective inducer of hepatic drug metabolism, especially involving pathways accomplished… CONTINUE READING
    Methadone--metabolism, pharmacokinetics and interactions.
    • 276
    • Open Access
    Induction of Drug Metabolising Enzymes
    • 122
    Paracetamol, alcohol and the liver.
    • 185
    • Open Access
    Clinically Significant Interactions with Drugs Used in the Treatment of Tuberculosis
    • 63


    Publications referenced by this paper.
    Oxidative and reductive metabolism by cytochrome P450 2E1
    • 557
    Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2.
    • 463
    Glucuronidation of Drugs
    • 158
    Influence of Diet and Nutritional Status on Drug Metabolism
    • 192
    Cytochrome P450 enzymes involved in acetaminophen activation by rat and human liver microsomes and their kinetics.
    • 378