Clinical and serological heterogeneity in patients with anticentromere antibodies.

OBJECTIVE To evaluate the clinical and serological heterogeneity in patients with anticentromere antibodies (ACA). METHODS One hundred twenty patients with ACA were analyzed retrospectively. ACA were detected initially on the basis of indirect immunofluorescence on HEp-2 cells, and then antibodies to CENP-B were measured by ELISA. Antibodies to other… (More)