Clinical and serologic parallels to APS-I in patients with thymomas and autoantigen transcripts in their tumors.

@article{Wolff2014ClinicalAS,
  title={Clinical and serologic parallels to APS-I in patients with thymomas and autoantigen transcripts in their tumors.},
  author={Anette S. B. Wolff and Jaanika K{\"a}rner and Jone Furlund Owe and Bergithe Eikeland Oftedal and Nils Erik Gilhus and Martina Moter Erichsen and Olle K{\"a}mpe and Anthony Meager and P{\"a}rt Peterson and Kai Kisand and Nick Willcox and Eystein Sverre Husebye},
  journal={Journal of immunology},
  year={2014},
  volume={193 8},
  pages={3880-90}
}
Patients with the autoimmune polyendocrine syndrome type I (APS-I), caused by mutations in the autoimmune regulator (AIRE) gene, and myasthenia gravis (MG) with thymoma, show intriguing but unexplained parallels. They include uncommon manifestations like autoimmune adrenal insufficiency (AI), hypoparathyroidism, and chronic mucocutaneous candidiasis plus autoantibodies neutralizing IL-17, IL-22, and type I IFNs. Thymopoiesis in the absence of AIRE is implicated in both syndromes. To test… CONTINUE READING

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