Clinical and radiological efficacy of initial vs delayed treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis.

@article{Kooij2009ClinicalAR,
  title={Clinical and radiological efficacy of initial vs delayed treatment with infliximab plus methotrexate in patients with early rheumatoid arthritis.},
  author={Sjoerd M van der Kooij and Saskia le Cessie and Yvonne P. M. Goekoop-Ruiterman and J K de Vries-Bouwstra and Derkjen van Zeben and Pit J. S. M. Kerstens and Johanna M. W. Hazes and Dirkjan van Schaardenburg and Ferdinand C. Breedveld and Ben A. C. Dijkmans and Cornelia F. Allaart},
  journal={Annals of the rheumatic diseases},
  year={2009},
  volume={68 7},
  pages={1153-8}
}
OBJECTIVES To compare the clinical and radiological efficacy of initial vs delayed treatment with methotrexate (MTX) and infliximab (IFX) in patients with recent onset rheumatoid arthritis (RA). METHODS In a post hoc analysis of the BeSt study (for Behandel Stratagieen, Dutch for treatment strategies), 117 patients who started initial MTX+IFX were compared with 67 patients who started MTX+IFX treatment after failing (disease activity score (DAS)>2.4; median delay to IFX: 13 months) on > or =3… CONTINUE READING

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