Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis

@article{Lucchinetti2008ClinicalAR,
  title={Clinical and radiographic spectrum of pathologically confirmed tumefactive multiple sclerosis},
  author={C. Lucchinetti and R. Gavrilova and I. Metz and J. Parisi and B. Scheithauer and S. Weigand and K. Thomsen and J. Mandrekar and A. Altıntaş and B. Erickson and F. K{\"o}nig and C. Giannini and H. Lassmann and L. Linbo and S. Pittock and W. Br{\"u}ck},
  journal={Brain},
  year={2008},
  volume={131},
  pages={1759 - 1775}
}
Atypical imaging features of multiple sclerosis lesions include size >2 cm, mass effect, oedema and/or ring enhancement. This constellation is often referred to as ‘tumefactive multiple sclerosis’. Previous series emphasize their unifocal and clinically isolated nature, however, evolution of these lesions is not well defined. Biopsy may be required for diagnosis. We describe clinical and radiographic features in 168 patients with biopsy confirmed CNS inflammatory demyelinating disease (IDD… Expand
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