Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial.

@article{GoekoopRuiterman2005ClinicalAR,
  title={Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): a randomized, controlled trial.},
  author={Yvonne P. M. Goekoop-Ruiterman and Jeska K. de Vries-Bouwstra and Cornelia F. Allaart and Derkjen van Zeben and Pit J.S.M. Kerstens and Johanna M. W. Hazes and Aelko H. Zwinderman and H. Karel Ronday and K. Huub Han and Marie Louise Westedt and Andreas H. Gerards and J H van Groenendael and Willem F. Lems and Michiel V van Krugten and Ferdinand C. Breedveld and Ben A. C. Dijkmans},
  journal={Arthritis and rheumatism},
  year={2005},
  volume={52 11},
  pages={
          3381-90
        }
}
OBJECTIVE Several treatment strategies have proven value in the amelioration of rheumatoid arthritis (RA), but the optimal strategy for preventing long-term joint damage and functional decline is unclear. We undertook this study to compare clinical and radiographic outcomes of 4 different treatment strategies, with intense monitoring in all patients. METHODS In a multicenter, randomized clinical trial, 508 patients were allocated to 1 of 4 treatment strategies: sequential disease-modifying… 

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