Clinical and psychological effects of marihuana in man.

@article{Weil1968ClinicalAP,
  title={Clinical and psychological effects of marihuana in man.},
  author={Andrew T. Weil and Norman Earl Zinberg and Judith M. Nelsen},
  journal={Science},
  year={1968},
  volume={162 3859},
  pages={
          1234-42
        }
}
In the spring of 1968 we conducted a series of pilot experiments on acute marijuana intoxication in human subjects. The study was not undertaken to prove or disprove popularly held convictions about marijuana as an intoxicant, to compare it with other drugs, or to introduce our own opinions. Our concern was simply to collect some long overdue pharmacological data. In this article we describe the primitive state of knowledge of the drug, the research problems encountered in designing a… Expand
Current Research on Marijuana
Pharmacological studies of marijuana during the past three years have confirmed most of the clinical effects of the drug reported before. The outstanding effects are an initial alteration of moodExpand
Marihuana in Man: Three Years Later
TLDR
The mechanisms by which marihuana alters mental functions are not likely to be answered in man, nor even answered soon by animal studies, so it may be necessary to look to additional animal studies to provide leads for pertinent future studies in man. Expand
The Pharmacology of Cannabis
TLDR
There is still a great deal of disagreement about the dangers of this drug and differences of opinion also exist concerning the subjective effects of the drug, which is obviously necessary to reserve judgment to some extent. Expand
Psychological studies of marijuana and alcohol in man
TLDR
Regular users of marijuana (cannabis sativa) were given smoked and orally administered marijuana, a placebo, or alcohol and appeared to be mild intoxicants in a laboratory setting. Expand
Pupillary constriction after marijuana smoking.
TLDR
A middle-aged woman who stated that while she was under the influence of marijuana she could chop onions without suffering excessive lacrimation found this experience was borne out among her friends after the use of this drug. Expand
EFFECTS OF MARIHUANA IN LABORATORY ANIMALS AND IN MAN
TLDR
Comparison of the results between the marihuanaas and Δ9‐THC showed that in man and in the laboratory animals marihuanas A and B induced effects two to four times greater than expected from their Δ9-THC content. Expand
METABOLISM AND DISPOSITION OF TETRAHYDROCANNABINOLS IN NÄIVE SUBJECTS AND CHRONIC MARIJUANA USERS
TLDR
It is therefore possible that Cannabis could be reinstituted in the physicians' armamentarium and of special importance to study the disposition and metabolism of A9-THC in man. Expand
TETRAHYDROCANNABINOL AND THE MARIJUANA‐INDUCED SOCIAL “HIGH,” OR THE EFFECTS OF THE MIND ON MARIJUANA *
TLDR
The results suggest that the subjective effects experienced by many marijuana smokers in this country are determined more by psychological factors than by the THC content of their cigarettes. Expand
Current concepts: marihuana--a medical review.
THE psychic and physiologic sequelae of the consumption of marihuana are of considerable medical interest. Although a substantial bibliography is available, it is frequently difficult to distinguishExpand
Pharmacology of Marihuana (Cannabis sativa)
TLDR
It appears that the farmers of colonial times were largely unaware of the pharmacologic potentiality of cannabis, and varieties of hemp selected for high fiber content were cultivated in North America when the major supply lines from the Orient were cut off during World War II. Expand
...
1
2
3
4
5
...

References

SHOWING 1-6 OF 6 REFERENCES
Measurement of mental clouding and other subjective effects of morphine.
  • G. Smith, H. Beecher
  • Medicine, Psychology
  • The Journal of pharmacology and experimental therapeutics
  • 1959
TLDR
Mental clouding and physical and mental inactivity are powerful morphine effects, for the first time, expressed here in quantitative terms. Expand
A comparison of the behavioral and physiological changes accompanying sleep deprivation and chlorpromazine administration in man.
  • A. Mirsky, P. Carson
  • Psychology, Medicine
  • Electroencephalography and clinical neurophysiology
  • 1962
TLDR
Of the three physiological measures, the EEG appeared to be the least accurate in reflecting variations in alterness, and the possible existence of separate, although closely related, mechanisms within the reticular activating system which mediate behavior on the one hand and the EEG, respiration and peripheral vasomotor tone on the other. Expand
Outsiders Studies in the Sociology of Deviance.
This 1966 paperback edition of a publication which first appeared in 1963 has by now been widely reviewed as a worthy contribution to the sociological study of deviant behavior. Its currentExpand
A TOTAL SYNTHESIS OF DL-DELTA-1-TETRAHYDROCANNABINOL, THE ACTIVE CONSTITUENT OF HASHISH.
A continuous performance test of brain damage.