Clinical and prognostic significance of chromosomal abnormalities in childhood acute myeloid leukemia de novo.

@article{MartnezCliment1995ClinicalAP,
  title={Clinical and prognostic significance of chromosomal abnormalities in childhood acute myeloid leukemia de novo.},
  author={Jos{\'e} Antonio Mart{\'i}nez-Climent and Nancy Jane Lane and Charles M. Rubin and Elaine Morgan and Helen S Johnstone and Rosemarie Mick and Sharon B. Murphy and James W. Vardiman and Richard A Larson and Michelle M Le Beau},
  journal={Leukemia},
  year={1995},
  volume={9 1},
  pages={95-101}
}
We report on the chromosomal pattern of 120 patients with childhood AML de novo. One hundred and fifteen patients (96%) had adequate samples for analysis; 98 (85%) of these showed clonal karyotypic abnormalities. They were classified into cytogenetic subgroups which were closely correlated with FAB subtypes: t(8;21) and M2 (n = 9); t(15;17) and M3 (n = 12); inv(16) and M4Eo (n = 9); t(9;11) and M5a (n = 10); t(11q23) other than t(9;11) and M4-M5 (n = 11); and t(1;22) and M7 (n = 4). In patients… CONTINUE READING
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