Clinical and prognostic role of circulating MMP-2 and its inhibitor TIMP-2 in HCC patients prior to and after trans-hepatic arterial chemo-embolization.

@article{Daniele2014ClinicalAP,
  title={Clinical and prognostic role of circulating MMP-2 and its inhibitor TIMP-2 in HCC patients prior to and after trans-hepatic arterial chemo-embolization.},
  author={Antonella Daniele and Rosa Divella and Michele Quaranta and Vittorio Mattioli and Porzia Casamassima and Angelo Virgilio Paradiso and Vito Michele Garrisi and Cosimo Damiano Gadaleta and Gennaro Gadaleta-Caldarola and Eufemia Savino and Rosanna Maci and Antonia Bellizzi and Vito Maria Fazio},
  journal={Clinical biochemistry},
  year={2014},
  volume={47 3},
  pages={184-90}
}
BACKGROUND AND AIMS Trans-hepatic arterial chemo-embolization is the most commonly used treatment for unresectable hepatocellular carcinoma. The prognostic impact of tumor biomarkers has not therefore been evaluated in this treatment. Imbalance between matrix metalloproteinase-2 and tissue inhibitor metalloproteinase-2 is considered to play an important role in extracellular matrix remodeling and degradation. Higher serum levels of MMP-2 have been shown to predict a poor prognosis and shorter… CONTINUE READING
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