Clinical and polysomnographic effects of trazodone CR in chronic insomnia associated with dysthymia

  title={Clinical and polysomnographic effects of trazodone CR in chronic insomnia associated with dysthymia},
  author={Liborio Parrino and Maria Cristin Spaggiari and Mirella Boselli and Guido Di Giovanni and Mario G. Terzano},
Six middle aged subjects complaining of chronic insomnia associated with dysthymia were investigated in a 2-month single blind study: a 7-day placebo treatment period, followed by a 6-week phase with increasing doses of trazodone controlled release (CR) formulation (50 mg through days 8–10; 75 mg through days 11–13; 150 mg through days 14–49) and then a final 7-day withdrawal period under placebo. Medication was always administered at bedtime. Five polysomnographic recordings were accomplished… CONTINUE READING
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