Clinical and pharmacologic aspects of blinatumomab in the treatment of B-cell acute lymphoblastic leukemia

  title={Clinical and pharmacologic aspects of blinatumomab in the treatment of B-cell acute lymphoblastic leukemia},
  author={Craig A Portell and Candice M. Wenzell and Anjali S. Advani},
  booktitle={Clinical pharmacology : advances and applications},
Acute lymphoblastic leukemia (ALL) in adults remains a challenging disease to treat, and novel therapies are needed. Precursor-B ALL comprises 80% of cases, and the CD19 antigen is expressed in nearly all precursor-B ALL patients. Bispecific T-cell-engaging antibodies are novel bioengineered proteins. The bispecific T-cell-engaging antibody blinatumomab engages polyclonal T cells to CD19-expressing B cells. By binding to both CD3 and CD19, blinatumomab physically brings these T cells in close… CONTINUE READING
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