Clinical and pathological significance of microsatellite instability in sporadic endometrial carcinoma.

@article{Caduff1996ClinicalAP,
  title={Clinical and pathological significance of microsatellite instability in sporadic endometrial carcinoma.},
  author={Rosmarie F Caduff and Carolyn M. Johnston and Suzette M. Svoboda-Newman and Ellen L. Poy and Sof{\'i}a D. Merajver and Thomas S. Frank},
  journal={The American journal of pathology},
  year={1996},
  volume={148 5},
  pages={1671-8}
}
Defective DNA mismatch repair in neoplasia is manifested by extra, aberrant bands within multiple microsatellite markers. The replication error (RER) phenotype is present in most colorectal and endometrial carcinomas in patients with the hereditary nonpolyposis colorectal carcinoma syndrome. In addition, a minority of sporadic colorectal and endometrial carcinomas are RER positive. RER in sporadic colorectal carcinomas has been associated with improved prognosis, but its clinical significance… CONTINUE READING