Clinical and pathological features of viral haemorrhagic disease of rabbits and the European brown hare syndrome.

  title={Clinical and pathological features of viral haemorrhagic disease of rabbits and the European brown hare syndrome.},
  author={Paolo Stefano Marcato and Cinzia Benazzi and G. Vecchi and Marco Galeotti and Leonardo Della Salda and Giuseppe Sarli and Pia Lucidi},
  journal={Revue scientifique et technique},
  volume={10 2},
The authors review the clinical, macro- and microscopical features, and pathogenesis of viral haemorrhagic disease (VHD) of rabbits and the European brown hare syndrome (EBHS). The two diseases share similar clinical and pathological manifestations involving an acute syndrome, sometimes accompanied by nervous and respiratory symptoms and epistaxis, and in all cases by severe hepatic damage and multifocal haemorrhages leading to fatal shock. The hepatic lesions (necrosis and inflammation) result… 

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Viral haemorrhagic disease of rabbits

- La malattia emorragica virale in Puglia . Contributo sperimentale

  • Riv . Coniglicoltura
  • 1990

- La maladie X des lapins

  • Cuniculture
  • 1988

- Malattia emorragica virale del coniglio

  • Obiet . Docum . vet .
  • 1989