Clinical and pathological features of alcohol-related brain damage

  title={Clinical and pathological features of alcohol-related brain damage},
  author={Natalie M. Zahr and Kimberley L Kaufman and Clive G. Harper},
  journal={Nature Reviews Neurology},
One of the sequelae of chronic alcohol abuse is malnutrition. Importantly, a deficiency in thiamine (vitamin B1) can result in the acute, potentially reversible neurological disorder Wernicke encephalopathy (WE). When WE is recognized, thiamine treatment can elicit a rapid clinical recovery. If WE is left untreated, however, patients can develop Korsakoff syndrome (KS), a severe neurological disorder characterized by anterograde amnesia. Alcohol-related brain damage (ARBD) describes the effects… CONTINUE READING