Clinical and pathological continuum of multisystem TDP-43 proteinopathies.

  title={Clinical and pathological continuum of multisystem TDP-43 proteinopathies.},
  author={Felix Geser and Maria Martinez-Lage and John Robinson and Kunihiro Uryu and Manuela Neumann and Nicholas J Brandmeir and Sharon X Xie and Linda K. Kwong and L. B. Elman and L. F. McCluskey and Chris M. Clark and Joe Malunda and Bruce L. Miller and Earl A. Zimmerman and Jiang Qian and Vivianna M Van Deerlin and Murray Grossman and Virginia M-Y Lee and John Q. Trojanowski},
  journal={Archives of neurology},
  volume={66 2},
OBJECTIVE To determine the extent of transactivation response DNA-binding protein with a molecular weight of 43 kDa (TDP-43) pathology in the central nervous system of patients with clinically and autopsy-confirmed diagnoses of frontotemporal lobar degeneration with and without motor neuron disease and amyotrophic lateral sclerosis with and without cognitive impairment. DESIGN Performance of immunohistochemical whole-central nervous system scans for evidence of pathological TDP-43 and… CONTINUE READING
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