Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17).

@article{Licht1995ClinicalAM,
  title={Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17).},
  author={J. Licht and C. Chomienne and A. Goy and A. Chen and A. Scott and D. Head and J. Michaux and Y. Wu and A. Deblasio and W. Miller},
  journal={Blood},
  year={1995},
  volume={85 4},
  pages={
          1083-94
        }
}
Analysis of a variant translocation t(11;17) in a case of acute promyelocytic leukemia (APL) led to discovery of a novel zinc finger gene, PLZF, fused to the retinoic acid receptor-alpha (RAR alpha) gene. We reviewed the clinical and molecular features of five additional patients with t(11;17)-associated APL. The clinical course of three patients was characterized by early death and three experienced disseminated intravascular coagulation. Morphologically all of the patients fell in a unusual… Expand
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References

SHOWING 1-10 OF 71 REFERENCES
Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid).
  • 1,197
The unique aspects of acute promyelocytic leukemia.
  • R. Stone, R. Mayer
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1990
  • 176
...
1
2
3
4
5
...