Clinical and molecular characterization of a re-established line of sheep exhibiting hemophilia A.

@article{Porada2010ClinicalAM,
  title={Clinical and molecular characterization of a re-established line of sheep exhibiting hemophilia A.},
  author={Christopher D. Porada and Chad D. Sanada and Charles R. Long and Julie A. Wood and Jayashree Basavaraj Desai and Newman Frederick and L. Millsap and Claudia Bormann and Suzanne Lynn Menges and Chloe Hanna and Gabriela Flores-Foxworth and Tadasu Shin and Mark E. Westhusin and Wen-ting Liu and Hudson A. Glimp and Esmail D. Zanjani and Jay N Lozier and Vladimir Pliska and Gerald F. Stranzinger and Hannes Joerg and Duane Carl Kraemer and Graça Almeida-Porada},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2010},
  volume={8 2},
  pages={
          276-85
        }
}
BACKGROUND Large animal models that accurately mimic human hemophilia A (HA) are in great demand for developing and testing novel therapies to treat HA. OBJECTIVES To re-establish a line of sheep exhibiting a spontaneous bleeding disorder closely mimicking severe human HA, fully characterize their clinical presentation, and define the molecular basis for disease. PATIENTS/METHODS Sequential reproductive manipulations were performed with cryopreserved semen from a deceased affected ram. The… CONTINUE READING
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