Clinical and molecular characteristics of malignant transformation of low-grade glioma in children.

  title={Clinical and molecular characteristics of malignant transformation of low-grade glioma in children.},
  author={Alberto Broniscer and Suzanne J. Baker and Alina Nico West and Melissa M Fraser and Erika Proko and Mehmet Koçak and James Dalton and Gerard P. Zambetti and David W. Ellison and Larry E. Kun and Amar Gajjar and Richard J. Gilbertson and Christine Fuller},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={25 6},
  • A. BroniscerS. Baker C. Fuller
  • Published 9 February 2007
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
PURPOSE To analyze the clinical and molecular characteristics of malignant transformation (MT) of low-grade glioma (LGG) in children. PATIENTS AND METHODS The clinical, radiologic, and histologic characteristics of children treated at our institution who experienced MT of LGG were reviewed. Molecular alterations in these tumors were analyzed by fluorescent in situ hybridization, immunohistochemistry, and TP53 sequencing. Cumulative incidence estimate and risk factors for MT were determined… 

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