Clinical and microbiological characteristics of Rhodotorula mucilaginosa infections in a tertiary-care facility.

Abstract

BACKGROUND Rhodotorula spp. are an emergent opportunistic pathogen, particularly in immunocompromised individuals. MATERIALS AND METHODS The aim of the study was to review reported cases of Rhodotorula infection over a period of 9 years to determine epidemiology, risk factors, treatment and outcome. RESULTS The Rhodotorula spp. were isolated from cerebrospinal fluid (9) and blood (5). The most common pre-disposing factors were prolonged hospital stay (>1 month) and prolonged usage of broad-spectrum antibiotics (>1 month). All the isolates were identified as R. mucilaginosa by conventional methods. Amphotericin B demonstrated lowest minimum inhibitory concentration (MIC) as compared with other anti-fungal agents (fluconazole, itraconazole and voriconazole). CONCLUSIONS The recognition of unusual yeasts as an agent of life-threatening infection and their intrinsic resistance increases the burden on the mycology laboratory for complete species identification and to determine minimum inhibitory concentration.

DOI: 10.4103/0255-0857.136576

Cite this paper

@article{Capoor2014ClinicalAM, title={Clinical and microbiological characteristics of Rhodotorula mucilaginosa infections in a tertiary-care facility.}, author={Malini Rajinder Capoor and Sanjeev Aggarwal and C Raghvan and Devendra Kumar Gupta and Aaron K. Jain and Ram Shankar Chaudhary}, journal={Indian journal of medical microbiology}, year={2014}, volume={32 3}, pages={304-9} }