Clinical and immunological effects of a synthetic Beta-human chorionic-gonadotropin vaccine.

@article{Triozzi1994ClinicalAI,
  title={Clinical and immunological effects of a synthetic Beta-human chorionic-gonadotropin vaccine.},
  author={Pierre L Triozzi and Diane Gochnour and E. W. Martin and Wayne Aldrich and Jane Powell and Jung Ah Kim and Donn C. Young and J. Lombardi},
  journal={International journal of oncology},
  year={1994},
  volume={5 6},
  pages={1447-53}
}
We treated 23 patients with non-trophoblastic cancers with escalating doses of a synthetic vaccine consisting of the carboxy-terminal peptide of beta human chorionic gonadotropin conjugated to diphtheria toroid (CTP37), a muramyl dipeptide as an adjuvant, and squalene/mannide monooleate as a vehicle. Toxicity consisted of pain and sterile abscess formation at the injection site and of constitutional symptoms. Diphtheria toxoid hypersensitivity developed in one patient. Immunizations elicited… CONTINUE READING

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