Clinical and immunologic responses to multiple doses of IMVAMUNE (Modified Vaccinia Ankara) followed by Dryvax challenge.

@article{Frey2007ClinicalAI,
  title={Clinical and immunologic responses to multiple doses of IMVAMUNE (Modified Vaccinia Ankara) followed by Dryvax challenge.},
  author={Sharon E. Frey and Frances K. Newman and Jeffrey S. Kennedy and Vera Sobek and Francis A. Ennis and Heather Hill and Lihan K Yan and Paul J. Chaplin and Jens Vollmar and Bernard R. Chaitman and Robert B. Belshe},
  journal={Vaccine},
  year={2007},
  volume={25 51},
  pages={8562-73}
}
Smallpox vaccination with replication deficient vaccinia strains such as Modified Vaccinia Ankara (MVA) may induce protective immunity with improved safety and tolerability profiles compared with currently available smallpox vaccines. Ninety subjects were randomized equally to six groups in a partially blinded, randomized, controlled clinical trial. IMVAMUNE (MVA-BN, Bavarian Nordic A/S, Kvistgård, Denmark) vaccine or placebo was administered at Study Days 0 and 28 by subcutaneous or… CONTINUE READING
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