Clinical and immune responses in resected colon cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen.

@article{Foon1999ClinicalAI,
  title={Clinical and immune responses in resected colon cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen.},
  author={Kenneth A. Foon and William J John and Mukul Chakraborty and R. K. Das and Alexander Teitelbaum and Juanita Garrison and Oscar L Kashala and Subir Kumar Chatterjee and Malaya Bhattacharya-Chatterjee},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1999},
  volume={17 9},
  pages={
          2889-5
        }
}
PURPOSE We generated an anti-idiotype antibody, designated CeaVac, that is an internal image of the carcinoembryonic antigen (CEA). We previously demonstrated that the majority of patients with advanced colorectal cancer generate specific anti-CEA responses. The purpose of the current study was to treat patients with surgically resected colon cancer with CeaVac to determine the immune response and clinical outcome to treatment with vaccine. We also compared the immune responses between patients… CONTINUE READING
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