• Medicine
  • Published in
    Clinical cancer research : an…
    1997

Clinical and immune responses in advanced colorectal cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen.

@article{Foon1997ClinicalAI,
  title={Clinical and immune responses in advanced colorectal cancer patients treated with anti-idiotype monoclonal antibody vaccine that mimics the carcinoembryonic antigen.},
  author={Kenneth A. Foon and William J. John and Mandira Chakraborty and A J Sherratt and Juanita Garrison and Magnus Flett and Malaya Bhattacharya-Chatterjee},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1997},
  volume={3 8},
  pages={
          1267-76
        }
}
Carcinoembryonic antigen (CEA) is expressed in a wide variety of adenocarcinomas, and it is well recognized that cancer patients are immunologically "tolerant" to CEA. The purpose of this study was to determine whether we could break immune tolerance to CEA by vaccinating patients with a monoclonal anti-idiotype antibody that is the internal image of CEA and to determine what impact this might have on patient survival. Twenty-four patients with advanced CEA-positive colorectal cancer who failed… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 37 CITATIONS

Anti-idiotypic antibodies as cancer vaccines: achievements and future improvements

  • Front. Oncol.
  • 2012
VIEW 3 EXCERPTS
CITES RESULTS & METHODS
HIGHLY INFLUENCED

Generation of anti-idiotypic reagents in the EGFRvIII tumor-associated antigen system

VIEW 5 EXCERPTS
CITES METHODS, RESULTS & BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

Phase II trial of irinotecan in patients with progressive or rapidly recurrent colorectal cancer.

  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 1996

Murine monoclonal anti - idiotype antibody induces a specific antibody response to human carcinoembryonic antigen ( CEA ) in cyno - molgus monkeys

M. Chakraborty, K. A. Foon, H. Kdhler, M. Bhattacharya-Chat-terjee
  • FASEB J .
  • 1994

A monoclonal anti - idiotypic antibody bearing the image of an epitope specific to the human carcinoembryonic antigen

F-i. Gaida, U.. Wagener Fenger, C., M. Neumaier
  • Int . J . Cancer .
  • 1992