Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria.

@article{Hawkins2009ClinicalAG,
  title={Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria.},
  author={Claudia A Hawkins and Beth Chaplin and John Ochola Idoko and Ernest Ekong and Isaac Adewole and Wadzani Gashau and Robert Murphy and Phyllis J Kanki},
  journal={Journal of acquired immune deficiency syndromes},
  year={2009},
  volume={52 2},
  pages={
          228-34
        }
}
INTRODUCTION The HIV-1 epidemic in African countries is largely due to non-B HIV-1 subtypes. Patterns and frequency of antiretroviral drug resistance mutations observed in these countries may differ from those in the developed world, where HIV-1 subtype B predominates. METHODS HIV-1 subtype and drug resistance mutations were assayed among Nigerian patients with treatment failure on first-line therapy (plasma HIV RNA >1000 copies/mL). Sequence analysis of the reverse transcriptase and protease… CONTINUE READING
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