Clinical and genotype studies of cardiac tumors in 154 patients with tuberous sclerosis complex.

@article{Jwiak2006ClinicalAG,
  title={Clinical and genotype studies of cardiac tumors in 154 patients with tuberous sclerosis complex.},
  author={Sergiusz J{\'o}źwiak and Katarzyna Kotulska and Jolanta Kasprzyk-Obara and Dorota Domańska-Pakieła and Małgorzata Tomyn-Drabik and Penelope S. Roberts and David J Kwiatkowski},
  journal={Pediatrics},
  year={2006},
  volume={118 4},
  pages={e1146-51}
}
OBJECTIVE Tuberous sclerosis complex is an autosomal dominant disorder in which hamartomas occur in several organs. Cardiac rhabdomyomas, the most common heart tumors of childhood, are well known to be associated with tuberous sclerosis complex. Our aim for this study was to characterize the incidence, progression, and clinical consequences of tuberous sclerosis complex-associated rhabdomyomas in a large cohort of patients with TSC1 and TSC2 genotypes. PATIENTS AND METHODS Patients (154) with… CONTINUE READING

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