Clinical and genetic issues in dilated cardiomyopathy: A review for genetics professionals

@article{Hershberger2010ClinicalAG,
  title={Clinical and genetic issues in dilated cardiomyopathy: A review for genetics professionals},
  author={Ray E. Hershberger and Ana Morales and Jill D. Siegfried},
  journal={Genetics in Medicine},
  year={2010},
  volume={12},
  pages={655-667}
}
Dilated cardiomyopathy (DCM), usually diagnosed as idiopathic dilated cardiomyopathy (IDC), has been shown to have a familial basis in 20–35% of cases. Genetic studies in familial dilated cardiomyopathy (FDC) have shown dramatic locus heterogeneity with mutations identified in >30 mostly autosomal genes showing primarily dominant transmission. Most mutations are private missense, nonsense or short insertion/deletions. Marked allelic heterogeneity is the rule. Although to date most DCM genetics… CONTINUE READING

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