• Corpus ID: 24116058

Clinical and genetic features of DYT1 and DYT5.

  title={Clinical and genetic features of DYT1 and DYT5.},
  author={Xiao-zhu Wang and Nanbert Zhong},
  journal={Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences},
  volume={38 1},
  • Xiao-zhu WangN. Zhong
  • Published 18 February 2006
  • Biology, Medicine
  • Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Dystonia is a syndrome which is characterized by sustained muscle contractions, producing twisting, repetitive, and patterned movements, or abnormal postures. According to genetic basis, dystonia is classified into 13 subtypes. We mainly discussed two subtypes, DYT1 and DYT5, in this review. Early-onset primary dystonia is caused by the mutation of DYT1 gene, which leads to TORSINA abnormal. GTP cyclohydrolase 1 (GTPCH1)-deficient DRD (DYT5) is caused by the mutations of GCH1 gene. By genetic… 
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