Clinical and genetic factors associated with sacroiliitis in Crohn's disease

  title={Clinical and genetic factors associated with sacroiliitis in Crohn's disease},
  author={Harald Peeters and Bert Vander Cruyssen and Herman Mielants and Kurt de Vlam and S{\'e}verine Vermeire and Edouard Louis and Paul J. Rutgeerts and Jacques Belaiche and Martine De Vos},
  journal={Journal of Gastroenterology and Hepatology},
Background and Aim:  Radiographic sacroiliitis (SI), often asymptomatic, is considered the most frequent extra‐intestinal manifestation (EIM) of Crohn's disease (CD). Data on the association of SI with other clinical features of CD are limited. Association of SI with CARD15 polymorphisms has recently been suggested. In a multicenter study, we investigated the association of SI in CD patients with clinical phenotypes, other EIM and CARD15 polymorphisms. 

Sacroiliitis is common in Crohn's disease patients with perianal or upper gastrointestinal involvement.

SI was as common among Korean IBD patients as among Western patients and perianal or upper-gastrointestinal involvement is associated with SI in CD patients.

Efficacy of Ustekinumab Against Spondyloarthritis Associated with Crohn’s Disease: A Case Report and Review of the Literature

A case of Crohn’s disease with SpA is reported, as an extraintestinal manifestation, in which ustekinumab proved extremely effective, not only for alleviating the arthritis but also against skin manifestations and scleritis.

Management of patients with inflammatory bowel disease and spondyloarthritis

The coexistence of IBD and SpA generates challenges and opportunities for both the gastroenterologist and the rheumatologist, and the potential of drugs with a gut-specific mode of action in the treatment of I BD-related arthritis warrants further exploration.

Enteropathic Spondyloarthritis: From Diagnosis to Treatment

Enteropathic arthritis is a spondyloarthritis which occurs in patients with inflammatory bowel diseases (IBDs) and other gastrointestinal diseases and the most popular theory supposes that joint inflammation occurs in genetically predisposed subjects with bacterial gut infections.

Clinical features and epidemiology of spondyloarthritides associated with inflammatory bowel disease.

The correct recognition of spondylarthropathies needs an integrated multidisciplinary approach in order to identify common therapeutic strategies, especially in the era of the new biologic therapies.

Association of inflammatory bowel disease with ankylosing spondylitis and rheumatoid arthritis: A nationwide population-based study

IBD is significantly associated with AS and RA in the large-scaled population-based study, which suggests that etiopathogenesis of IBD might be shared withAS and RA.

The Prevalence and Clinical Associations of Subclinical Sacroiliitis in Inflammatory Bowel Disease.

Sacroiliitis is underdiagnosed in IBD and is associated with male sex, arthritis, and inflammatory CD, and data support targeted screening in at-risk patients.

A Review of Extraintestinal Manifestations and Complications of Inflammatory Bowel Disease

  • V. Annese
  • Medicine
    Saudi journal of medicine & medical sciences
  • 2019
This review provides a summary of the most common EIMs in IBD and their prevalence and management.

Immunologic and genetic links between spondylarthropathies and inflammatory bowel diseases.

Clinical and experimental evidences regarding the immunological and genetic links between gut and joint inflammation in IBDs and SpA are reviewed, suggesting the most important pathway now emerging is the IL-23/IL-17 axis.

Inflammatory bowel disease associated arthropathy

There remains a great need for larger, randomized studies to address optimal therapy of IBD associated arthropathy, with treatment with biologic agents not always sufficient for control of arthritis.



Lack of association of HLA B27 with radiographic sacroiliitis in inflammatory bowel disease.

: In 89 patients with inflammatory bowel disease, only one out of 11 patients with radiographic sacroiliitis was found to possess the HLA B27 antigen, while three out of four patients with ankylosing

Lack of association of HLA B27 with radiographic sacroiliitis in inflammatory bowel disease.

In 89 patients with inflammatory bowel disease, only one out of 11 patients with radiographic sacroiliitis was found to possess the HLA B27 antigen, while three out of four patients with ankylosing

Quantitative sacroiliac scintigraphy in patients with Crohn's disease.

There was no correlation in the group as a whole between radiologic and/or scintigraphic evidence of sacroiliitis and the tissue antigen HLA-B27.

Radiological sacroiliitis, a hallmark of spondylitis, is linked with CARD15 gene polymorphisms in patients with Crohn’s disease

CARD15 variants were identified as genetic predictors of Crohn’s disease related sacroiliitis and an association was demonstrated between these polymorphisms and an extraintestinal manifestation of Cro bowel disease.

Subclinical Sacroiliitis in Inflammatory Bowel Disease: A Clinical and Follow-up Study

There is a high prevalence of isolated subclinical sacroiliitis in IBD, which may represent a forme fruste of enteropathic ankylosing spondylitis, a stunted form of axial involvement because of therapy, or a third category of rheumatic disease associated with IBD.

Spondyloarthropathy is underestimated in inflammatory bowel disease: prevalence and HLA association.

Articular involvement in IBD can be classified as SpA and it is related to disease duration, suggesting evidence for a related pathogenic mechanism.

Peripheral arthropathies in inflammatory bowel disease: their articular distribution and natural history

Enteropathic peripheral arthropathy without axial involvement can be subdivided into a pauciarticular, large joint arthropivity, and a bilateral symmetrical polyarthropathy, each being distinguished by its articular distribution and natural history.

Prevalence of ankylosing spondylitis and other spondyloarthropathies among patients with inflammatory bowel disease: a population study (the IBSEN study).

AS occurred frequently in patients with newly diagnosed IBD, and IBP did not seem to predispose to AS or other forms of SpA, indicating that IBP is not a precursor or manifestation of spondyloarthropathies in Patients with IBD.

Ankylosing spondylitis and bowel disease.

HLA B27 in regional enteritis with and without ankylosing spondylitis or sacroiliitis.

The incidence of B27 in patients with ankylosing spondylitis associated with regional enteritis was significantly lower than in ankylosing spondylitis without inflammatory bowel disease. It was