Clinical and genetic factors associated with sacroiliitis in Crohn's disease

@article{Peeters2008ClinicalAG,
  title={Clinical and genetic factors associated with sacroiliitis in Crohn's disease},
  author={H. Peeters and B. Vander Cruyssen and H. Mielants and K. de Vlam and S. Vermeire and E. Louis and P. Rutgeerts and J. Belaiche and M. De Vos},
  journal={Journal of Gastroenterology and Hepatology},
  year={2008},
  volume={23}
}
Background and Aim:  Radiographic sacroiliitis (SI), often asymptomatic, is considered the most frequent extra‐intestinal manifestation (EIM) of Crohn's disease (CD). Data on the association of SI with other clinical features of CD are limited. Association of SI with CARD15 polymorphisms has recently been suggested. In a multicenter study, we investigated the association of SI in CD patients with clinical phenotypes, other EIM and CARD15 polymorphisms. 
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References

SHOWING 1-10 OF 53 REFERENCES
Lack of association of HLA B27 with radiographic sacroiliitis in inflammatory bowel disease.
: In 89 patients with inflammatory bowel disease, only one out of 11 patients with radiographic sacroiliitis was found to possess the HLA B27 antigen, while three out of four patients with ankylosingExpand
Lack of association of HLA B27 with radiographic sacroiliitis in inflammatory bowel disease.
In 89 patients with inflammatory bowel disease, only one out of 11 patients with radiographic sacroiliitis was found to possess the HLA B27 antigen, while three out of four patients with ankylosingExpand
Clinical patterns in Crohn's disease: a statistical study of 615 cases.
TLDR
Results of a study of 615 consecutive patients with Crohn's disease seen at the Cleveland Clinic from 1966 through 1969 are reported, finding that initial anatomic involvement bears directly on the clinical course and prognosis. Expand
Quantitative sacroiliac scintigraphy in patients with Crohn's disease.
TLDR
There was no correlation in the group as a whole between radiologic and/or scintigraphic evidence of sacroiliitis and the tissue antigen HLA-B27. Expand
Radiological sacroiliitis, a hallmark of spondylitis, is linked with CARD15 gene polymorphisms in patients with Crohn’s disease
TLDR
CARD15 variants were identified as genetic predictors of Crohn’s disease related sacroiliitis and an association was demonstrated between these polymorphisms and an extraintestinal manifestation of Cro bowel disease. Expand
Subclinical Sacroiliitis in Inflammatory Bowel Disease: A Clinical and Follow-up Study
TLDR
There is a high prevalence of isolated subclinical sacroiliitis in IBD, which may represent a forme fruste of enteropathic ankylosing spondylitis, a stunted form of axial involvement because of therapy, or a third category of rheumatic disease associated with IBD. Expand
Spondyloarthropathy is underestimated in inflammatory bowel disease: prevalence and HLA association.
TLDR
Articular involvement in IBD can be classified as SpA and it is related to disease duration, suggesting evidence for a related pathogenic mechanism. Expand
Peripheral arthropathies in inflammatory bowel disease: their articular distribution and natural history
TLDR
Enteropathic peripheral arthropathy without axial involvement can be subdivided into a pauciarticular, large joint arthropivity, and a bilateral symmetrical polyarthropathy, each being distinguished by its articular distribution and natural history. Expand
Prevalence of ankylosing spondylitis and other spondyloarthropathies among patients with inflammatory bowel disease: a population study (the IBSEN study).
TLDR
AS occurred frequently in patients with newly diagnosed IBD, and IBP did not seem to predispose to AS or other forms of SpA, indicating that IBP is not a precursor or manifestation of spondyloarthropathies in Patients with IBD. Expand
Ankylosing spondylitis and bowel disease.
TLDR
It is suggested that targeted therapies for Crohn's disease could also be effective for intestinal as well as extra-intestinal disease manifestations in spondyloarthropathy, as evidenced by the recent studies on TNF-alpha blockade and unravelling the gut-synovium axis in spONDyloarthopathy. Expand
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