Clinical and genetic evaluation of thirty ovarian cancer families.

@article{Zweemer1998ClinicalAG,
  title={Clinical and genetic evaluation of thirty ovarian cancer families.},
  author={Ronald P. Zweemer and Ren{\'e} H. M. Verheijen and Jan JP Gille and Paul J van Diest and Gerald Pals and Fred H. Menko},
  journal={American journal of obstetrics and gynecology},
  year={1998},
  volume={178 1 Pt 1},
  pages={85-90}
}
OBJECTIVES Our purpose was to determine the prevalence of BRCA1 and BRCA2 germline mutations among patients from ovarian cancer families and to evaluate age at diagnosis, histologic diagnosis, and International Federation of Gynecology and Obstetrics stage in this group. STUDY DESIGN We reviewed 50 ovarian cancer patients from 30 ovarian cancer families and compared relevant clinical characteristics with those of a cancer registry reference group. BRCA1 (exons 2 to 24) and BRCA2 (exon 11… CONTINUE READING

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