Clinical and genetic aspects of trigonocephaly: a study of 25 cases.

@article{Azimi2003ClinicalAG,
  title={Clinical and genetic aspects of trigonocephaly: a study of 25 cases.},
  author={Cyrus Azimi and Shelley J Kennedy and David C Chitayat and Pranesh Chakraborty and Joe Clarke and Christopher Forrest and Ahmad Said Teebi},
  journal={American journal of medical genetics. Part A},
  year={2003},
  volume={117A 2},
  pages={127-35}
}
We reviewed 25 patients ascertained through the finding of trigonocephaly/metopic synostosis as a prominent manifestation. In 16 patients, trigonocephaly/metopic synostosis was the only significant finding (64%); 2 patients had metopic/sagittal synostosis (8%) and in 7 patients the trigonocephaly was part of a syndrome (28%). Among the nonsyndromic cases, 12 were males and 6 were females and the sex ratio was 2 M:1 F. Only one patient with isolated trigonocephaly had an affected parent (5.6… CONTINUE READING