Clinical and experimental approaches to the pathophysiology of interleukin-18 in cancer progression

  title={Clinical and experimental approaches to the pathophysiology of interleukin-18 in cancer progression},
  author={Fernando Vidal-Vanaclocha and Lorea Mendoza and Naiara Teller{\'i}a and Clarisa Salado and Mar{\'i}a A Valc{\'a}rcel and Natalia Gallot and Teresa Carrascal and Eider Egilegor and Jabier Beaskoetxea and Charles A Dinarello},
  journal={Cancer and Metastasis Reviews},
Interleukin-18 (IL-18, interferon [IFN]-gamma-inducing factor) is a proinflammatory cytokine converted to a biologically active molecule by interleukin (IL)-1beta converting enzyme (caspase-1). A wide range of normal and cancer cell types can produce and respond to IL-18 through a specific receptor (IL-18R) belonging to the toll-like receptor family. The activity of IL-18 is regulated by IL-18-binding protein (IL-18bp), a secreted protein possessing the ability to neutralize IL-18 and whose… CONTINUE READING


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Interleukin-18 upregulates very late antigen-4 expression from melanoma cell variants of low intracellular glutathione content, via oxidative stress-induced autocrine tumor necrosis factor-alpha

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Highly Influential
3 Excerpts

Interleukin-18 mediates proangiogenic action of vascular endothelial growth factor on myofibroblast and endothelial cell recruitment into hepatic melanoma metastasis. Hepatology

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