Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan.

@article{Meisenberg2015ClinicalAC,
  title={Clinical and cellular roles for TDP1 and TOP1 in modulating colorectal cancer response to irinotecan.},
  author={Cornelia Meisenberg and Duncan C Gilbert and Anthony J. Chalmers and V Haley and Simon W Gollins and Simon E Ward and Sherif F El-Khamisy},
  journal={Molecular cancer therapeutics},
  year={2015},
  volume={14 2},
  pages={
          575-85
        }
}
Colorectal cancer is the third most common cancer in the world. Despite surgery, up to 50% of patients relapse with incurable disease. First-line chemotherapy uses the topoisomerase 1 (TOP1) poison irinotecan, which triggers cell death by trapping TOP1 on DNA. The removal of TOP1 peptide from TOP1-DNA breaks is conducted by tyrosyl-DNA phosphodiesterase 1 (TDP1). Despite putative roles for TDP1 and TOP1 in colorectal cancer, their role in cellular and clinical responses to TOP1-targeting… CONTINUE READING

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