[Clinical and biological studies in the Bernard-Soulier syndrome (author's transl)].

  • G M Tobelem
  • Published 1976 in Nouvelle revue française d'hématologie


Bernard-Soulier syndrome is a rare constitutional thrombopathy, the main clinical feature is a bleeding tendency which is variable. The long bleeding time, in spite of a normal or little decreased platelet count, has been recently explained: the giant platelets have a defective adhesion to subendothelium. This abnormal adhesion could be related with an abnormal pattern of platelet membrane glycoproteins. Interactions between vessel wall, von Willebrand's factor and platelets are discussed.

Cite this paper

@article{Tobelem1976ClinicalAB, title={[Clinical and biological studies in the Bernard-Soulier syndrome (author's transl)].}, author={G M Tobelem}, journal={Nouvelle revue française d'hématologie}, year={1976}, volume={16 3}, pages={407-11} }