Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock

@article{Marchant1995ClinicalAB,
  title={Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock},
  author={Alan Marchant and Mar{\'i}a Luz S{\'a}nchez Alegre and Antoine M. Hakim and G{\'e}rald E. Pi{\'e}rard and Ga{\"e}tan Mar{\'e}caux and Gary Friedman and Donat De Groote and Robert J. Kahn and Jean Louis Vincent and Michael J. Goldman},
  journal={Journal of Clinical Immunology},
  year={1995},
  volume={15},
  pages={266-273}
}
Interleukin-10 is a potent macrophage-deactivating cytokine that inhibits lipopolysaccharide-induced tumor necrosis factor production. We determined the plasma levels of immunoreactive interleukin-10 in 16 patients with septic shock and in 11 patients with circulatory shock of nonseptic origin. In septic shock, interleukin-10 levels peaked during the first 24 h (median: 48 pg/ml) and decreased progressively till Day 5. In nonseptic shock, interleukin-10 plasma levels also increased during the… CONTINUE READING

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