Clinical and biological significance of hepsin overexpression in breast cancer.

  title={Clinical and biological significance of hepsin overexpression in breast cancer.},
  author={Peng Xing and Ji-guang Li and Feng Jin and Ting-ting Zhao and Qun Liu and Hui-ting Dong and Xiao-lin Wei},
  journal={Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
  volume={59 5},
OBJECTIVE Although many studies have documented the tumor-promoting role of hepsin in several types of malignancies, little is known about its clinical and biological significance in breast cancer. MATERIALS AND METHODS Hepsin expression was examined in 4 pairs of fresh breast tumor samples and corresponding nontumor breast tissues by Western blotting. Immunohistochemistry for hepsin was performed on an additional cohort of 215 archival breast cancer samples. The clinical significance of… CONTINUE READING
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