Clinical and biological significance of GSK-3β inactivation in breast cancer-an immunohistochemical study.

Abstract

Glycogen synthase kinase 3β, recently found to be functionally abnormal in various types of human disease, is negatively regulated by the PI3K/Akt signaling pathway. As Akt is constitutively activated in a subset of breast cancer, we hypothesized that glycogen synthase kinase 3β is inappropriately inactivated in these cases. In this study, we aimed to… (More)
DOI: 10.1016/j.humpath.2010.04.015

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