Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas

@article{Joo2008ClinicalAB,
  title={Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas},
  author={Kyeung Min Joo and Shi Yean Kim and Xun Jin and Sang Yong Song and D Z Kong and Jung-Ii Lee and Ji Won Jeon and Mi Hyan Kim and Bong Gu Kang and Yong Jung and Juyoun Jin and S N Hong and Woong-Yang Park and Dong-Sup Lee and Hyunggee Kim and Do-Hyun Nam},
  journal={Laboratory Investigation},
  year={2008},
  volume={88},
  pages={808-815}
}
A number of recent reports have demonstrated that only CD133-positive cancer cells of glioblastoma multiforme (GBM) have tumor-initiating potential. These findings raise an attractive hypothesis that GBMs can be cured by eradicating CD133-positive cancer stem cells (CSCs), which are a small portion of GBM cells. However, as GBMs are known to possess various genetic alterations, GBMs might harbor heterogeneous CSCs with different genetic alterations. Here, we compared the clinical… CONTINUE READING
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Cancer stem cells as mediators of treatment resistance in brain tumors : status and controversies

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