Clinical and biological impact of cyclin-dependent kinase subunit 2 in esophageal squamous cell carcinoma.

@article{Kita2014ClinicalAB,
  title={Clinical and biological impact of cyclin-dependent kinase subunit 2 in esophageal squamous cell carcinoma.},
  author={Yoshiaki Kita and Yuka Nishizono and Hiroshi Okumura and Yasuto Uchikado and Ken Sasaki and Masataka Matsumoto and Tetsuro Setoyama and Kiyonori Tanoue and Itaru Omoto and Shinichiro Mori and Tetsuhiro Owaki and Sumiya Ishigami and Hiroshi Nakagawa and Fumiaki Tanaka and Koshi Mimori and Masaki Mori and Shoji Natsugoe},
  journal={Oncology reports},
  year={2014},
  volume={31 5},
  pages={
          1986-92
        }
}
Cyclin-dependent kinase subunit 2 (CKS2) is a cyclin-dependent kinase subunit (CKS) family member that participates in cell cycle regulation. Few studies have investigated its involvement in esophageal squamous cell carcinoma (ESCC). The aim of the present study was to assess the clinical significance of CKS2 in ESCC. We used immunohistochemistry to study the clinicopathologic significance of CKS2 protein expression in 121 patients with ESCC. Using real-time reverse transcriptase-polymerase… 
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Cyclin-Dependent Kinase Regulatory Subunit 2 Indicated Poor Prognosis and Facilitated Aggressive Phenotype of Hepatocellular Carcinoma
TLDR
In vitro assays showed that CKS2 expression was higher in HCC cell lines than in normal liver cells, suggesting that it was a novel prognostic biomarker and potential target of HCC.
Up-regulated CKS 2 promotes tumor progression and predicts a poor prognosis in human colorectal cancer
TLDR
The study reveal that CKS2 is promising prognostic indicator and contributes to tumor progression in CRC, and support that C KS2-related signaling may represent a novel target for CRC therapy.
Up-regulated CKS2 promotes tumor progression and predicts a poor prognosis in human colorectal cancer.
TLDR
The study reveal that CKS2 is promising prognostic indicator and contributes to tumor progression in CRC, and support that C KS2-related signaling may represent a novel target for CRC therapy.
CKS2 in human cancers: Clinical roles and current perspectives (Review).
TLDR
CKS2 is commonly elevated in cancer, most likely due to its ability to promote cancer cell growth, invasion and migration through regulating certain significant genes.
CKS2 modulates cell cycle progression of tongue squamous cell carcinoma (TSCC) cells partly via modulating the cellular distribution of DUTPase.
TLDR
CKS2 expression is associated with unfavorable survival of patients with tongue squamous cell carcinoma, andhibiting its expression could reduce tongue Squamouscell carcinoma cell growth and induce G2/M arrest.
CKS2 Overexpression Correlates with Prognosis and Immune Cell Infiltration in Lung Adenocarcinoma: A Comprehensive Study based on Bioinformatics and Experiments
TLDR
High C KS2 expression was associated with poor prognosis and low levels of infiltrating immune cells in LUAD as well as with malignant phenotypes, suggesting that CKS2 may be a promising prognostic biomarker and therapeutic target inLUAD.
Original Article Up-regulated CKS2 promotes tumor progression and predicts a poor prognosis in human colorectal cancer
TLDR
It is revealed that CKS2 is promising prognostic indicator and contributes to tumor progression in CRC, and support that C KS2-related signaling may represent a novel target for CRC therapy is supported.
CKS2 (CDC28 protein kinase regulatory subunit 2) is a prognostic biomarker in lower grade glioma: a study based on bioinformatic analysis and immunohistochemistry
TLDR
It is demonstrated that CKS2 might be a candidate prognostic biomarker for LGG and could predict the survival rates of LGG patients.
Mitochondrial Function of CKS2 Oncoprotein Links Oxidative Phosphorylation with Cell Division in Chemoradioresistant Cervical Cancer1
MicroRNA-7 inhibits proliferation, migration and invasion of thyroid papillary cancer cells via targeting CKS2.
TLDR
It is demonstrated for the first time that miR-7 functions as a tumor suppressor and plays an important role in inhibiting the tumorigenesis through targeting CKS2 in thyroid papillary cancer cells.
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