Clinical and Virological Characteristics of Ebola Virus Disease Patients Treated With Favipiravir (T-705)-Sierra Leone, 2014.

Abstract

BACKGROUND  During 2014-2015, an outbreak of Ebola virus disease (EVD) swept across parts of West Africa. No approved antiviral drugs are available for Ebola treatment currently. METHODS  A retrospective clinical case series was performed for EVD patients in Sierra Leone-China Friendship Hospital. Patients with confirmed EVD were sequentially enrolled and treated with either World Health Organization (WHO)-recommended supportive therapy (control group) from 10 to 30 October, or treated with WHO-recommended therapy plus favipiravir (T-705) from 1 to 10 November 2014. Survival and virological characteristics were observed for 85 patients in the control group and 39 in the T-705 treatment group. RESULTS  The overall survival rate in the T-705 treatment group was higher than that of the control group (56.4% [22/39] vs 35.3% [30/85]; P = .027). Among the 35 patients who finished all designed endpoint observations, the survival rate in the T-705 treatment group (64.8% [11/17]) was higher than that of the control group (27.8% [5/18]). Furthermore, the average survival time of the treatment group (46.9 ± 5.6 days) was longer than that of the control group (28.9 ± 4.7 days). Most symptoms of patients in the treatment group improved significantly. Additionally, 52.9% of patients who received T-705 had a >100-fold viral load reduction, compared with only 16.7% of patients in the control group. CONCLUSIONS  Treatment of EVD with T-705 was associated with prolonged survival and markedly reduced viral load, which makes a compelling case for further randomized controlled trials of T-705 for treating EVD.

Cite this paper

@article{Bai2016ClinicalAV, title={Clinical and Virological Characteristics of Ebola Virus Disease Patients Treated With Favipiravir (T-705)-Sierra Leone, 2014.}, author={Changqing Bai and Jin-song Mu and David Kargbo and Ya-Bin Song and Wen-kai Niu and Wei-min Nie and Alex B. J. Kanu and Weiwei Liu and Yao-ping Wang and Foday Mohamed Dafae and Tao Yan and Yi Hu and Yong-qiang Deng and Hui-jun Lu and Fan Yang and Xiao-guang Zhang and Yang Sun and Yu-xi Cao and Hao-Xiang Su and Yu Sun and Wen-Sen Liu and Cheng-Yu Wang and Jun Qian and L. Liu and Hong Wang and Yi-gang Tong and Ze-yuan Liu and Yun-Song Chen and Hong-quan Wang and Brima Kargbo and George F. Gao and Jia-fu Jiang}, journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America}, year={2016}, volume={63 10}, pages={1288-1294} }