Clinical and Therapeutic Implications of Follistatin in Solid Tumours.

  title={Clinical and Therapeutic Implications of Follistatin in Solid Tumours.},
  author={Lei Shi and Jeyna Resaul and Sioned Owen and Lin Ye and Wen Jiang},
  journal={Cancer genomics & proteomics},
  volume={13 6},
Follistatin (FST), as a single-chain glycosylated protein, has two major isoforms, FST288 and FST315. The FST315 isoform is the predominant form whilst the FST288 variant accounts for less than 5% of the encoded mRNA. FST is differentially expressed in human tissues and aberrant expression has been observed in a variety of solid tumours, including gonadal, gastric and lung cancer, hepatocellular carcinoma, basal cell carcinoma and melanoma. Based on the current evidence, FST is an antagonist of… CONTINUE READING
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