Clinical and Radiologic Disease in Smokers With Normal Spirometry.

  title={Clinical and Radiologic Disease in Smokers With Normal Spirometry.},
  author={Elizabeth A. Regan and David A. Lynch and Douglas Curran-Everett and Jeffrey L Curtis and John H. M. Austin and Philippe A. Grenier and H U Kauczor and William Carl Bailey and Dawn L. DeMeo and Richard H Casaburi and Paul J. Friedman and E. J. R. van Beek and John E. Hokanson and Russell P Bowler and Terri H. Beaty and George R. Washko and Meilan Han and Victor Kim and Song Soo Kim and Kunihiro Yagihashi and Lacey Washington and Charlene E McEvoy and Clint Tanner and David M Mannino and Barry J. Make and Edwin K. Silverman and James D. Crapo},
  journal={JAMA internal medicine},
  volume={175 9},
IMPORTANCE Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow obstruction may assume that they are disease free. OBJECTIVE To identify clinical and radiologic evidence of smoking-related disease in a cohort of current and former smokers who did not meet spirometric criteria for COPD, for whom we adopted the discarded label of Global Initiative for Obstructive Lung Disease (GOLD) 0… CONTINUE READING


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