Clinical and Metabolic Characterization of Lean Caucasian Subjects With Non-alcoholic Fatty Liver

  title={Clinical and Metabolic Characterization of Lean Caucasian Subjects With Non-alcoholic Fatty Liver},
  author={Alexandra Feldman and Sebastian K. Eder and Thomas Klaus Felder and Lyudmyla Kedenko and Bernhard Paulweber and Andreas Stadlmayr and U Huber-Sch{\"o}nauer and David Niederseer and Felix Stickel and Simon Auer and Elisabeth Haschke-Becher and Wolfgang Patsch and Christian Datz and Elmar Aigner},
  journal={The American Journal of Gastroenterology},
Objectives:Non-alcoholic fatty liver disease (NAFLD) is closely linked to obesity; however, 5–8% of lean subjects also have evidence of NAFLD. We aimed to investigate clinical, genetic, metabolic and lifestyle characteristics in lean Caucasian subjects with NAFLD.Methods:Data from 187 subjects allocated to one of the three groups according to body mass index (BMI) and hepatic steatosis on ultrasound were obtained: lean healthy (BMI≤25 kg/m2, no steatosis, N=71), lean NAFLD (BMI≤25 kg/m2… 
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Some data suggest that the prevalence of steatohepatitis and advanced fibrosis do not differ significantly between lean and obese NAFLD; however, the former tend to have less severe disease at presentation, and the underlying pathophysiology of leanNAFLD may be quite different.
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